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Date:
Mon, 19 Oct 1998 17:47:02 -0400
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Lactation Information and Discussion <[log in to unmask]>
Subject:
DHE-45
From:
"Dr. Tom Hale" <[log in to unmask]>
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To :  Jan
Re :  DHE-45

Sorry, but its really unlikely that DHE-45 is going to work in this patient,
and it was an especially poor choice to use in this mother.  A little
morphine or sumatriptan (Imitrex) would have probably been better.  It
should be obvious that the ergotamine is suppressing lactation via its
powerful inhibition of prolactin production.

Unfortunately I do not know, and cannot yet find, the length of suppression
following ergot exposure,  but I would assume that prolactin production
could be restimulated with enough stimulation and some Reglan (30-40
mg/day).  But I would imagine the earlier the better.

With other ergots (cabergoline), after 24-48 hrs of therapy, prolactin is
continually inhibited thereafter.

Regards
Tom Hale

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