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Sender:
Lactation Information and Discussion <[log in to unmask]>
Date:
Sun, 5 Apr 1998 13:44:18 +0000
Reply-To:
Lactation Information and Discussion <[log in to unmask]>
Subject:
antiepileptic medication
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From:
newman <[log in to unmask]>
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cc: Chris352 <[log in to unmask]>
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Instead of automatically saying gabapentin is contraindicated, why not
do some studies of concentration in the milk?  Maybe no studies have
been done yet.  I will bet the neurologist and pediatrician are just
assuming this drug is contraindicated.

The information I have (I don't have a lot though) shows oral
bioavailability to be relatively low (59%), and plasma levels ranging
from 1-10 microg/ml.  If the m:p is 1, a premature baby getting 300
ml/day would 100-1000 microg/day.  This seems quite low to me.

Jack Newman, MD, FRCPC

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