To : Jan Aiken
Re : Cabergoline (Dostinex)

From my new edition:

Cabergoline is a long-acting synthetic ergot alkaloid derivative which
produces a dopamine agonist effect similar but much safer than bromocriptine
(Parlodel).   Cabergoline directly inhibits prolactin secretion by the
pituitary.   It is primarily indicated for pathological hyperprolactinemia,
but in several European studies, it has been used for inhibition of post-
partum lactation.  In several European countries, cabergoline is indicated
for the inhibition or suppression of physiologic lactation.  The dose
regimen used for the inhibition of physiologic lactation is cabergoline 1 mg
administered as a single dose on the first day post-partum.   For the
suppression of established lactation,  cabergoline 0.25 mg is taken every 12
hours for 2 days for a total of 1 mg.   Single doses of 1 mg have been found
to completely  inhibit postpartum lactation.  Transfer into human milk is
not reported.






Regards

Tom Hale, Ph.D.

http://neonatal.ttuhsc.edu/lact/