To : Jan Aiken Re : Cabergoline (Dostinex) From my new edition: Cabergoline is a long-acting synthetic ergot alkaloid derivative which produces a dopamine agonist effect similar but much safer than bromocriptine (Parlodel). Cabergoline directly inhibits prolactin secretion by the pituitary. It is primarily indicated for pathological hyperprolactinemia, but in several European studies, it has been used for inhibition of post- partum lactation. In several European countries, cabergoline is indicated for the inhibition or suppression of physiologic lactation. The dose regimen used for the inhibition of physiologic lactation is cabergoline 1 mg administered as a single dose on the first day post-partum. For the suppression of established lactation, cabergoline 0.25 mg is taken every 12 hours for 2 days for a total of 1 mg. Single doses of 1 mg have been found to completely inhibit postpartum lactation. Transfer into human milk is not reported. Regards Tom Hale, Ph.D. http://neonatal.ttuhsc.edu/lact/