On Sun, 1 Jun 2003 10:45:28 -0400, Lloyd Spear <[log in to unmask]>
wrote:

>2.  Amitraz and fulvalinate are so closely related that resistance to
>fluvalinate will result in resistance to amitraz in a very short time.
>However, the chemicals are not identical so if resistance has not

Amitraz: target site is octopamine (a biogenic amine) receptor.
Octopamine is a neurotransmitter in insects, but only a neuromodulator
in mammals.

Fluvalinate: target site is voltage gated sodium channels, important in
generating action potentials in the nervous system, in all animals.

these are very different target sites, as different as the target site of
coumaphos (organophosphate),  which is acetocholinesterase.

For technical  information on varroa mite resistance to fluvalinate and
sodium channel mutations, please see a new paper
http://cyberbee.msu.edu/huangpub/2002JAR.pdf

Zach
http://cyberbee.msu.edu

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