> Adverse effects of fumagillin have been discovered. After the treatment of Nosema apis-infected bees with fumagillin the electron-density of the mitochondrial matrix in corpora allata increased and the dimensions of the mitochondria diminished in comparison with untreated infected bees. 

> Fumagillin produced certain effects on the secretion granules of the hypopharyngeal glands of bees which increased and had a homogeneous structure, which is explained by the changes in the secretory activities of glands. It was confirmed that fumagillin largely increased mortality in bees as well as the number of fungi.

>Our results concerning the increased frequencies of chromosome aberrations (poliploidy, aneuploidy, gaps, acentrics and insertions) induced by fumagillin lead to the conclusion that fumagillin residues in food may have genotoxic effects that could increase the risk for chromosome aberrations and cancer.

Z. STANIMIROVIĆ ET AL. 2010

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