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Date: | Sun, 5 Feb 2023 09:05:39 -0500 |
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Vaccine news from the manufacturer, Dalan
In Dalan's newsletter, they offered a little more on the live virus challenge assay they used after vaccination. You can sign up for their newsletter with the link below and follow the rollout. Also, you can register as an early adapter. The price is unavailable, and the vaccine has not been field tested, making it difficult to evaluate participation.
>In order to satisfy the regulatory requirements for vaccine efficacy, the challenge dose must be established that consistently kills a proportion of larvae so that correct statistical tests may be used. Dalan found that the challenge dose required was up to 200 times more than the dose of P. larvae that has been described to establish an infection in larvae. This is not unusual in biological testing – very often these laboratory conditions for establishing immunity are many times more severe than in the field. The registration trial was completed by vaccinating queen bees in queen cages for 8 days, allowing them to return to hives, and lay eggs. Larvae were retrieved (grafted) at ≤1 day of age and submitted to a challenge of ~2,000 spores of P. larvae in the lab. At the end of the blinded and placebo-controlled experiment, the data indicated that there was a significant difference between control and vaccinated groups, and that efficacy was between 30 and 50%. This means that in a given infectious situation with this very high level of AFB spore load, one can expect at least 30 to 50% larval survival.
https://www.dalan.com/product
The Dalan vaccine is based on inducing trans-generational immune priming by feeding the queen immune elicitors (inactive P larvae particles ) that boost the colony's immunity. TGIP also occurs with natural infection. But with natural infection, we generally kill the adult bee population without considering that the adults, who are also feeding virus particles to the queen, are accomplishing the same immune priming. A safe way to harvest the genes from naturally occurring TGIP may also be helpful. Shook-swarms for AFB is one way that comes to mind.
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