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Date: | Fri, 31 Oct 2008 10:30:43 EDT |
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Thanks to Jim for doing the math about ppb - now, two warnings.
Parts per billion is not a universally consistent term. What we in the U.S.
define as PPB IS NOT what much of the rest of the English speaking world
call PPB.
Second, when reading ANY European dose response literature, you have to be
very careful about a term called mg% sneaking into the reported results.
One also sometimes sees this term in Medical literature. That throws
another factor of 100 into the equation - and ITS A COMMON mistake made - to not
recognize this term for what it is and adjust the reported dose to the true
dose - especially when literature is translated from another language into
English.
Finally, much of the pesticide testing is done by feeding - and you have to
consider whether each bee actually consumed the calculated amount.
However, some testing uses contact toxicity. In the lab, this consists of
putting a small drop (microliter) containing the chemical onto the body of
each tested bee. Tricky thing here is that the bees are usually put to sleep to
facilitate this - but many labs hit the bees too hard with the anaesthesia
OR use too much carrier chemical, inducing a high mortality of controls. The
error is then compounded when the investigator fails to adjust for control
mortality in the final report.
Larry Atkins and I had long conversation about this. If you do it right,
your control mortality should be less than 5%. That is NOT the case for many
of the trials that I've reviewed.
Jerry
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