This research was done in Rambam Medical Center in Haifa, Israel. It would have been nice if one of the conclusions would have been to encourage breastfeeding. Sincerly, Toby Gish RN, IBCLC, Haifa Israel

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11227343&dopt=Abstract

      Acta Paediatr. 2001 Jan;90(1):93-5.  Related Articles, Links  


Importance of insulin content in infant diet: suggestion for a new infant formula.

Shehadeh N, Gelertner L, Blazer S, Perlman R, Solovachik L, Etzioni A.

Department of Pediatrics, Rambam Medical Center, Haifa, Israel. [log in to unmask]

Oral insulin promotes intestinal maturation and may prevent diabetes in animal models. The aim of this study was to evaluate the concentration of insulin in human milk and in different infant formulas. Our results show that the concentration of insulin in human milk is significantly higher (60.23 +/- 41.05 microU/ml mean +/- SD) compared with cow's milk (16.32 +/- 5.98 microU/ml mean +/- SD) and that insulin is hardly detectable in infant formulas. We propose the addition of human insulin to infant formula to match its composition more closely to human milk.

PMID: 11227343 [PubMed - indexed for MEDLINE] 

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An additional interesting research on insulin and human milk by the same team is:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12719395&dopt=Abstract

      Arch Dis Child Fetal Neonatal Ed. 2003 May;88(3):F214-6.    

  
Insulin in human milk: postpartum changes and effect of gestational age.

Shehadeh N, Khaesh-Goldberg E, Shamir R, Perlman R, Sujov P, Tamir A, Makhoul IR.

Department of Neonatology, Meyer Children's Hospital, Rambam Medical Center, Bat-Galim, Haifa 31096, Israel.

OBJECTIVE: To determine if human milk insulin (HMI) concentrations are affected by gestational age and postnatal age. DESIGN AND SETTING: An observational study carried out in a level III neonatal intensive care unit. Insulin concentrations were determined in human milk of 90 parturient mothers who delivered between 30 and 41 weeks gestation. Samples were collected on days 3 and 10 after delivery. RESULTS: HMI concentrations for mothers of preterm infants were not significantly different from those of full term infants, on either day 3 or 10 post partum. When results for all 90 mothers were pooled, regardless of gestational age, HMI concentration fell significantly from day 3 to day 10 (50.1 (34.6) v 41.1 (28.5) microU/ml; p = 0.01; mean (SD)). However, this decrease was only significant for mothers delivering at term (37-41 weeks). CONCLUSIONS: HMI concentrations were not influenced by gestational age at delivery. They decreased post partum, mainly in mothers of term infants. The postnatal changes in HMI concentrations and the effects of oral insulin on the immature intestinal mucosa warrant further investigation.

PMID: 12719395 [PubMed - indexed for MEDLINE] 
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