We use Synthroid (Levothyroxine or T4) for our infants in the NICU.

Source:   2001 Neofax by Thomas E. Young MD and Barry Mangum, PharmD. (pg.
181)
    Dose and Administration:  Initial oral dose:  10-14 mcg/Kg per dose
orally every 24 hours.
              Dose is adjusted in 12.5 mcg. increments.
    Use :  Treatment of hypothyroidism
    Special Considerations/Preparations :  oral suspension is not
commercially available.
                (Must be compounded).  Mix suspension in a small amount of
sterile water or breast milk.
                Use immediately.


This source would indicate that mixing with breast milk would not cause a
problem with absorption.
I don't have a more current Neofax.  Does someone else have a newer source?

Hope this helps.

Ann Slaughter RNC, IBCLC

> ------------------------------
>
> Date:    Fri, 5 Mar 2004 05:25:52 -0500
> From:    "Kermaline J. Cotterman" <[log in to unmask]>
> Subject: Thyroxin
>
> <In terms of the mechanisms involved, Dr. Conrad said that animal studies
> have shown that soy interferes with the intestinal absorption of
> levothyroxine, resulting in fecal loss of the drug.>
>
> I was given specific directions to take my Synthroid on an empty stomach
> at least 30 minutes before food, in order not to interfere with the
> absorption. (I am just presuming this might apply to Thyroxin given an
> infant.) So unless a way were available to give the infant dose in water,
> I wonder how even breast milk might effect the absorption?? Has anyone
> had to give Thyroxin to their infant?
>
> Jean
> ************
> K. Jean Cotterman RNC, IBCLC
> Dayton, Ohio USA
>
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