Another study showing the lack of positive effects of formula that
contains DHA and AA.
Sincerely,
Andrea Eastman, MA, IBCLC
Granville, Ohio
mailto:[log in to unmask]
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http://taylorandfrancis.metapress.com/openurl.asp?genre=article&issn=080
3-5253&volume=91&issue=9&spage=942
Acta Paediatrica
Volume 91, Number 9/2002
Pages: 942 - 950
Dietary supplementation of long-chain polyunsaturated fatty acids in
preterm infants: effects on cerebral maturation
G Van Wezel-Meijler , M.S Van Der Knaap , J Huisman , E.J Jonkman , J
Valk , H.N Lafeber
Abstract:
Aim: To study the influence of dietary-supplied long-chain
polyunsaturated fatty acids on structural brain maturation in preterm
infants and to investigate parameters of functional brain development,
relating them to structural maturation. Other studies have suggested
that dietary supplementation of long-chain polyunsaturated fatty acids
in preterm infants may enhance their visual development. The influence
on structural brain development has never been evaluated.
Methods: In a prospective, double-blind study, 42 formula-fed premature
infants were randomized to be fed either a standard preterm formula
without long-chain polyunsaturated fatty acids or an identical formula
supplemented with docosahexaenoic acid (0.015 g/100 ml) and arachidonic
acid (0.031 g/100 ml). Infants with significant cerebral damage,
retinopathy, chronic disease or feeding problems were excluded.
Follow-up was focused on assessment of cerebral myelination by MRI.
Psychomotor, mental and visual development was analysed and flash-visual
evoked potentials were recorded.
Results: It was found that progress of myelination, mental and motor
development and latencies of visual evoked potentials were not
positively influenced by supplementation of long-chain polyunsaturated
fatty acids. At each test age, visual acuity was slightly better in the
supplemented infants than in the non-supplemented infants, but the
difference never reached significance level
Conclusion: Supplementation of long-chain polyunsaturated fatty acids
did not have a demonstrable positive influence on structural brain
maturation. Related to this finding, in this small cohort of preterm
infants without significant neurological damage, sample size being
restricted by strict inclusion criteria and MRI procedures, no
significant positive effects were found on psychomotor, mental and
visual development.
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