Blood. 2009 Jan 5. [Epub ahead of print]

Improved outcome of allogeneic bone marrow transplantation due to breast-feeding-induced tolerance to maternal antigens.

Aoyama K, Koyama M, Matsuoka KI, Hashimoto D, Ichinohe T, Harada M, Akashi K, Tanimoto M, Teshima T.

Biopathological Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.

Exposure
of offspring to noninherited maternal antigens (NIMAs) during pregnancy
may have an impact on transplants performed later in life. Using a
mouse model, we recently showed that bone marrow transplantation (BMT)
from NIMA-exposed offspring to the mother led to a reduction of
graft-versus-host disease (GVHD). Since offspring can also be exposed
to NIMAs by breast-feeding after birth, we tested whether breast milk
could mediate the tolerogenic NIMA effect. We found that oral exposure
to NIMAs by breast-feeding alone was sufficient to reduce GVHD, and
that in utero exposure to NIMAs is required for maximum reduction of
GVHD. The tolerogenic milk effects disappeared when donor mice were
injected with CD25 monoclonal antibodies during the lactation period,
suggesting a CD4(+) CD25(+) regulatory T-cell-dependent mechanism. Our
results suggest a previously unknown impact of breast-feeding on the
outcome of transplantation.

PMID: 19124834 [PubMed - as supplied by publisher]

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