Hello all,
Another example of there being no normal group of exclusively breastfed
infants in studies. Though within their own constraints, it does show that
switching a baby to even an "extensively hydrolyzed formula" did not get good
results. Lansoprazole is Prevacid.
_http://www.docguide.com/news/content.nsf/PaperFrameSet?OpenForm&refid=2218&sp
ecid=77&id=5962CC8C6C80A843852568E4004A0343&newsid=852571020057CCF68525741F003
11F44&prevpage=0&u=GOTO//www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&d
b=PubMed&dopt=Abstract&list_uids=18376260&ref_
(http://www.docguide.com/news/content.nsf/PaperFrameSet?OpenForm&refid=2218&specid=77&id=5962CC8C6C80A8438525
68E4004A0343&newsid=852571020057CCF68525741F00311F44&prevpage=0&u=GOTO//www.nc
bi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uid
s=18376260&ref) =
_J Pediatr Gastroenterol Nutr._ (javascript:AL_get(this, 'jour', 'J Pediatr
Gastroenterol Nutr.');) 2008 Mar;46(3):352-4.
Clinical response to 2 dosing regimens of lansoprazole in infants with
gastroesophageal reflux.
_Khoshoo V_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Khoshoo%20V"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPane
l.Pubmed_RVAbstract) , _Dhume P_
(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Dhume%20P"[Author]&itool=EntrezSystem2.PEntrez.Pubmed
.Pubmed_ResultsPanel.Pubmed_RVAbstract) .
West Jefferson Medical Center, 1111 Medical Center Blvd, South 650, Marrero,
LA 70072, USA. [log in to unmask]
Proton pump inhibitors such as lansoprazole are used in the treatment of
gastroesophageal reflux disease (GERD), but dosing guidelines for infants have
not been determined. The objective of this study was to assess the clinical
efficacy of 2 dosing regimens of lansoprazole in infants with GERD using the
revised infant gastroesophageal reflux questionnaire scores (I-GERQ-R). Thirty
consecutive infants (3-7 months) with GERD, whose conditions were diagnosed
by I-GERQ-R scores of > or =16, were randomly assigned to receive 1 of 2
lansoprazole dosing regimens: 15 mg given once per day (group A) or approximately
7.5 mg given 2 times per day (group B). Matched infants in a control group
were treated with an extensively hydrolyzed formula (group C). Daily I-GERQ-R
scores were gathered, and the scores after 1 and 2 weeks of treatment were
used for analysis. The mean pretreatment scores were similar in groups A, B, and
C (26.6, 26.9, and 25.9, respectively). After treatment there was a similar
drop in the mean scores in groups A and B (20.6 and 20.0, respectively), but
not in group C (25.8). At the end of the first week of treatment, in group A,
5 of 15 infants (33%) had a significant reduction in their I-GERQ-R scores,
whereas in group B, 10 of 15 infants (67%) had a significant reduction in
their I-GERQ-R scores (P < 0.05). At the end of the second week of treatment,
groups A and B had similar numbers of patients with significant improvement
(60% and 67%), which was higher than in group C (3/15, 20%). Overall, there was
no difference in the symptom response, as measured by I-GERQ-R scores,
between 15 mg of lansoprazole given once per day and 7.5 mg given twice per day in
infants with GERD, but the twice-daily regimen produced a faster symptom
response. Both regimens were significantly better than treatment of infants with
an extensively hydrolyzed formula.
PMID: 18376260 [PubMed - in process]
Peace,
Judy
Judy LeVan Fram, PT, IBCLC, LLLL
Brooklyn, NY, USA
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