I am back from weeks of NOMAIL until I go to Haiti again in March and am back to
monitoring medication issues.

RE: Clozapine

Briggs cites the following article:
Barmas C, Bergant A, Hummer M, Fleischacker WW (1994).  Clozapine concentration
in maternal and fetal plasma, amniotic fluid and breast milk.  Am J Psychiatr,
151, 943.

Briggs states that clozapine is concentrated in breast milk, and only cites the
data, states that the infant was not allowed to breastfeed, and gives no
recommendations.

Bennett in Drugs and Human Lactation states that limited data suggest that when
clozapine is administered to a nursing mother the quantity of drug that passes
into milk is small.  Bennett does give a recommendation, though: the inherent
toxicity of the drug with the risk of agranulocytosis suggests, however, that
the mother should not breastfeed.

Frank J. Nice, DPA, CPHP