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Subject:
nabumetone (Relafen)
From:
newman <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Sun, 28 Sep 1997 10:00:59 -0500
Content-Type:
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text/plain (10 lines) 
According to Dr. Hale's book, this NSAID has a protein binding of 99% (very good), oral
availability of 38% (also very good).  It does have a long half life (about 20 hours), so why not
try ibuprofen (half life about 2 hours)?  The NSAID's, despite company propaganda to the
contrary are really all about the same.  Ibuprofen does have 80% bioavailability, so from this
point of view it is less good.

Probably both are quite acceptable with breastfeeding.

Jack Newman, MD, FRCPC

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