To:    Deborah Codding:
Subject: pseudoephedrine

  I noted with interest several of the posts which indicated that Sudafed(
pseudoephedine) reduced milk supply,  I've not seen this documented anywhere
else,  I'd like to hear more about this.
Otherwise,  Pseudoephedrine is a mild sympathomimetic that selectively(more
or less) constricts the nasal mucosa.  Although limited,  it can produce
mild stimulation in some individuals.   It is useful clinically as a
decongestant,  with an adult dose of 60 mg q 6 hrs.   A 30 mg dose is
generally too small to work in most adults.     Only 0.5-0.7% of the
maternal dose is reported to transfer into human milk.

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To Dr. Ahrendsen
Subject:  Radiocontrast agents

  From a certain unmentionable book .....

RADIOPAQUE AGENTS

Category = Radio-contrast agents
Agents include:  Omnipaque,  Conray,  Cholebrine, Telepaque, Oragrafin,
Bilivist, Hypaque, Gastrografin, Renovue-Dip, Angiovist,  Optiray , etc.
Radiopaque agents(except barium) are iodinated compounds used to visualize
various organs during X-ray, CAT scans, and other radiological procedures.
These compounds are highly iodinated benzoic acid  derivatives.  Although
under usual circumstances, iodine products are contraindicated in nursing
mothers(due to ion trapping in milk),  these products are unique in that
they extremely inert.   According to the manufactures,  less than 0.005%  of
the iodine is free.   They are in essence pharmacologically inert,  not
metabolized,  and are rapidly excreted by the kidney(80-90% with 24 hrs).
They are known to pass unchanged into human milk after IV administration.
They are not absorbed after oral administration( < 0.1% absorption).
Although most  company inserts suggest that infants be removed from the
breast for 24 hours,  no untoward effects have been reported with these
products.
AHL= 20-90 min.  M/P=                        PB= 0-10%
PHL=                        PK = < 1 hr




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T.W. Hale, Ph.D.
Associate Professor of Pediatrics
Texas Tech University School of Medicine

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