Jaquie have you tried e-Lactancia?  [log in to unmask] It it's not in their data base, they will do their best to find out and send a helpful reply. 

Jean Ridler  RN  RM  IBCLC
Cape Town, South Africa



-----Original Message-----
From: Lactation Information and Discussion <[log in to unmask]> On Behalf Of Cindy Garrison BS IBCLC RLC
Sent: Friday, 21 May 2021 13:59
To: [log in to unmask]
Subject: Re: denosumab

Jacque,

Hale classifies it as an L4 - Possibly hazardous. He states there are no studies available on its transfer to human breast milk. The manufacturer advises against its use. The molecular weight is very large and the amount in breastmilk is expected to be exceptionally low, per Hale. He goes on to say that there are no long term data on the safety of using this type of drug in breastfeeding mothers. He also includes this statement: "Furthermore, there are current data that suggest that some monoclonal antibody drugs do transfer into milk, and perhaps the breastfed infant. Therefore, some caution is recommended and each woman should understand the benefits and risk of using this type of medication."

Cindy Garrison BS IBCLC

Date: Fri, 21 May 2021 11:40:43 +1200
From: Jacquie Nutt <[log in to unmask]>
Subject: denosumab

Hello everyone

Is there anyone who knows of a mother having denosumab subcutaneously and breastfeeding an older baby (this one is a 10 month old.) This 2021 information implies that there is little theoretical risk, but no evidence at all. Concern is mostly for prem babies and newborns.

https://www.ncbi.nlm.nih.gov/books/NBK500588/#:~:text=Until%20more%20data%20become%20available,immunoglobulin%20G2%20(IgG2)%20antibody
.

The mum is distraught at being told to wean but she is at risk of losing her leg due to a giant cell tumour of the knee. She's putting off the treatment, which is bad because the tumour is growing and destroying her bones.

Best wishes
Jacquie Nutt IBCLC

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End of LACTNET Digest - 19 May 2021 to 20 May 2021 (#2021-39)
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