The absorption of cinitapride (12mg) following oral administration was rapid, with peak levels being achieved 2 h after dosing; absorption following intramuscular administration (4mg) was even more rapid, with peak levels (50% more that oral levels) being achieved 1 h after dosing.

There is not much other pharmacokinetic  information that I could find on cinitapride, let alone breastfeeding information, but, after the sixth month of breastfeeding, and especially at two years, almost every drug is compatible with breastfeeding, and this should also be so for cinitapride.

To be even more assured, just avoid breastfeeding for approximately three hours after breastfeeding as the drug peaks in plasma two hours after being taken and would be the same for any drug that got into breast milk.

The symptoms of overdose include drowsiness, confusion and extrapyramidal effects, so just monitor the breastfed child for these possible adverse effects to be extra sure.

There is no need to discontinue breastfeeding in this case.



Frank J. Nice, RPh, DPA, CPHP



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