Hi,

I attach the information from the website that Jean mentioned.
http://www.e-lactancia.org/breastfeeding/denosumab/product/



Alba Padró
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El vie, 21 may 2021 a las 19:40, Jean Ridler (<[log in to unmask]>)
escribió:

> Jaquie have you tried e-Lactancia?  [log in to unmask] It it's not
> in their data base, they will do their best to find out and send a helpful
> reply.
>
> Jean Ridler  RN  RM  IBCLC
> Cape Town, South Africa
>
>
>
> -----Original Message-----
> From: Lactation Information and Discussion <[log in to unmask]>
> On Behalf Of Cindy Garrison BS IBCLC RLC
> Sent: Friday, 21 May 2021 13:59
> To: [log in to unmask]
> Subject: Re: denosumab
>
> Jacque,
>
> Hale classifies it as an L4 - Possibly hazardous. He states there are no
> studies available on its transfer to human breast milk. The manufacturer
> advises against its use. The molecular weight is very large and the amount
> in breastmilk is expected to be exceptionally low, per Hale. He goes on to
> say that there are no long term data on the safety of using this type of
> drug in breastfeeding mothers. He also includes this statement:
> "Furthermore, there are current data that suggest that some monoclonal
> antibody drugs do transfer into milk, and perhaps the breastfed infant.
> Therefore, some caution is recommended and each woman should understand the
> benefits and risk of using this type of medication."
>
> Cindy Garrison BS IBCLC
>
> Date: Fri, 21 May 2021 11:40:43 +1200
> From: Jacquie Nutt <[log in to unmask]>
> Subject: denosumab
>
> Hello everyone
>
> Is there anyone who knows of a mother having denosumab subcutaneously and
> breastfeeding an older baby (this one is a 10 month old.) This 2021
> information implies that there is little theoretical risk, but no evidence
> at all. Concern is mostly for prem babies and newborns.
>
>
> https://www.ncbi.nlm.nih.gov/books/NBK500588/#:~:text=Until%20more%20data%20become%20available,immunoglobulin%20G2%20(IgG2)%20antibody
> .
>
> The mum is distraught at being told to wean but she is at risk of losing
> her leg due to a giant cell tumour of the knee. She's putting off the
> treatment, which is bad because the tumour is growing and destroying her
> bones.
>
> Best wishes
> Jacquie Nutt IBCLC
>
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