http://www.medscape.com/viewarticle/838612?nlid=78600_451&src=wnl_edit_medp_peds&uac=65312MN&spon=9


  The Association Between Breastfeeding and Childhood Obesity: A
  Meta-analysis


        Abstract

*Background* The increase in childhood obesity is a serious public 
health concern. Several studies have indicated that breastfed children 
have a lower risk of childhood obesity than those who were not 
breastfed, while other studies have provided conflicting evidence. The 
objective of this meta-analysis was to investigate the association 
between breastfeeding and the risk of childhood obesity.

*Methods* The PubMed, EMBASE and CINAHL Plus with Full Text databases 
were systematically searched from start date to 1^st August 2014. Based 
on the meta-analysis, pooled adjusted odds ratio (AOR) and 95% 
confidence interval (CI) were calculated. I^2 statistic was used to 
evaluate the between-study heterogeneity. Funnel plots and Fail-safe N 
were used to assess publication bias and reliability of results, and 
results from both Egger test and Begg test were reported.

*Results* Twenty-five studies with a total of 226,508 participants were 
included in this meta-analysis. The studies' publication dates ranged 
from 1997 to 2014, and they examined the population of 12 countries. 
Results showed that breastfeeding was associated with a significantly 
reduced risk of obesity in children (AOR = 0.78; 95% CI: 0.74, 0.81). 
Categorical analysis of 17 studies revealed a dose-response effect 
between breastfeeding duration and reduced risk of childhood obesity.

*Conclusion* Results of our meta-analysis suggest that breastfeeding is 
a significant protective factor against obesity in children.


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