Dear Lactnet Friends:
And the expensive and wasteful effort to create human milk in a can
continues............
BMC Pediatr. <http://www.ncbi.nlm.nih.gov/pubmed/23072617#> 2012 Oct
17;12(1):164.
The influence of a formula supplemented with dairy lipids and plant oils on
the erythrocyte membrane omega-3 fatty acid profile in healthy full-term
infants: a double-blind randomized controlled trial.
Gianń ML<http://www.ncbi.nlm.nih.gov/pubmed?term=Giann%C3%AC%20ML%5BAuthor%5D&cauthor=true&cauthor_uid=23072617>
, Roggero P<http://www.ncbi.nlm.nih.gov/pubmed?term=Roggero%20P%5BAuthor%5D&cauthor=true&cauthor_uid=23072617>
, Baudry C<http://www.ncbi.nlm.nih.gov/pubmed?term=Baudry%20C%5BAuthor%5D&cauthor=true&cauthor_uid=23072617>
, Ligneul A<http://www.ncbi.nlm.nih.gov/pubmed?term=Ligneul%20A%5BAuthor%5D&cauthor=true&cauthor_uid=23072617>
, Morniroli D<http://www.ncbi.nlm.nih.gov/pubmed?term=Morniroli%20D%5BAuthor%5D&cauthor=true&cauthor_uid=23072617>
, Garbarino F<http://www.ncbi.nlm.nih.gov/pubmed?term=Garbarino%20F%5BAuthor%5D&cauthor=true&cauthor_uid=23072617>
, Ruyet P<http://www.ncbi.nlm.nih.gov/pubmed?term=Ruyet%20P%5BAuthor%5D&cauthor=true&cauthor_uid=23072617>
, Mosca F<http://www.ncbi.nlm.nih.gov/pubmed?term=Mosca%20F%5BAuthor%5D&cauthor=true&cauthor_uid=23072617>
.
AbstractABSTRACT:
BACKGROUND: Human milk is the optimal nutrition for infants. When
breastfeeding is not possible, supplementation of infant formula with long
chain polyunsaturated fatty acids appears to promote neurodevelopmental
outcome and visual function. Plant oils, that are the only source of fat in
most of infant formulas, do not contain specific fatty acids that are
present in human and cow milk and do not encounter milk fat triglyceride
structure. Experimental data suggest that a mix of dairy lipids and plant
oils can potentiate endogenous synthesis of n-3 long chain polyunsaturated
fatty acids. This trial aims to determine the effect of an infant formula
supplemented with a mixture of dairy lipids and plant oils on the
erythrocyte membrane omega-3 fatty acid profile in full-term infants
(primary outcome). Erythrocyte membrane long chain polyunsaturated fatty
acids and fatty acids content, the plasma lipid profile and the
insulin-growth factor 1 level, the gastrointestinal tolerance, the changes
throughout the study in blood fatty acids content, in growth and body
composition are evaluated as secondary outcomes.
METHODS:
In a double-blind controlled randomized trial, 75 healthy full-term infants
are randomly allocated to receive for four months a formula supplemented
with a mixture of dairy lipids and plant oils or a formula containing only
plant oils or a formula containing plant oils supplemented with arachidonic
acid and docosahexaenoic acid. Twenty-five breast-fed infants constitute
the reference group. Erythrocyte membrane omega-3 fatty acid profile, long
chain polyunsaturated fatty acids and the other fatty acids content, the
plasma lipid profile and the insulin-growth factor 1 level are measured
after four months of intervention. Gastrointestinal tolerance, the changes
in blood fatty acids content, in growth and body composition, assessed by
means of an air displacement plethysmography system, are also evaluated
throughout the study.
DISCUSSION:
The achievement of an appropriate long chain polyunsaturated fatty acids
status represents an important goal in neonatal nutrition. Gaining further
insight in the effects of the supplementation of a formula with dairy
lipids and plant oils in healthy full-term infants could help to produce a
formula whose fat content, composition and structure is more similar to
human milk. Trial registration ClinicalTrials.gov Identifier NCT01611649.
warmly,
Nikki Lee RN, BSN, Mother of 2, MS, IBCLC, CCE, CIMI, ANLC, CKC
craniosacral therapy practitioner
www.breastfeedingalwaysbest.com
https://www.facebook.com/nikkileehealth
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