Debbie writes:


Mother (one month post partum) has idiopathic thrombocytopenia  and is in 
the hospital for treatment.  She will be receiving Privigen (IV  Ig)  I 
cannot find this in Hale nor searching the Lactnet archives.   Does anyone know 
if this is compatible with breastfeeding?  I need an  answer asap.



~~~
Info open to all, on the web:
_http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~rbViU4:1_ 
(http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~rbViU4:1) 
 
...Excerpt..."
    Globulin, Immune
CASRN:  9007-83-4  
For other data, click on the Table of  Contents


Effects in Breastfed Infants: 
In a  retrospective study of 108 women with relapsing-remitting multiple 
sclerosis, 69  received intravenous immunoglobulin (IVIG) postpartum. Those 
who received IVIG  received either 0.4 g/kg daily for 5 days plus additional 
doses of 0.4 g/kg at 6  and 12 weeks postpartum (n = 41), or IVIG 0.4 g/kg 
daily for 5 days during the  first 6 to 8 weeks of pregnancy, then 0.4 g/kg 
every 6 weeks until 12 weeks  postpartum. Seventy-three percent of the 108 
infants were breastfed until 3 to  12 weeks postpartum. No serious adverse 
event occurred in any of the infants and  the mothers who breastfed had outcomes 
as good as those who did not.[6]

A  case series reported 43 women with multiple sclerosis who received 60 
grams of  IVIG within 3 days of delivery and 10 grams monthly. All of the 
women breastfed  their infants for at least 4 weeks. The only adverse effect 
reported in infants  was a transient rash one day after a maternal dose of IVIG 
which was possibly  caused by the IVIG. The relapse rate was lower than 
with historical controls who  did not receive IVIG.[7]

A European double-blind, randomized trial  compared two IVIG regimens in 
168 postpartum mothers with multiple sclerosis to  observe the relapse rate. 
One group received 150 mg/kg within 24 hours of  delivery and monthly for 6 
months. The other group received 450 mg/kg within 24  hours of delivery, 300 
mg/kg on day 2 and 150 mg/kg on day 3 postpartum followed  by monthly doses 
of 150 mg/kg until 6 months postpartum. More mothers who  breastfed for 3 
months or longer were relapse free during the study than those  who did not 
breastfed or who breastfed less than 3 months. In all, 91 mothers  breastfed 
for 3 months or longer and 48 mothers breastfed for less than 3  months. No 
mention was made of adverse effects in breastfed infants.[4]"
 
Peace,
Judy


Judy LeVan  Fram, PT, IBCLC, LLLL
Brooklyn, NY,  USA
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