J Pediatr Gastroenterol Nutr
No mention of not breastfeeding... 



J Pediatr Gastroenterol Nutr. 1993 Aug;17(2):207-10.Hepatitis B virus in the colostra of HBeAg-positive carrier mothers.Lin HH, Hsu HY, Chang MH, Chen PJ, Chen DS.Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan, R.O.C.



To

investigate the amount of hepatitis B virus (HBV) in colostra of

hepatitis B e antigen (HBeAg)-positive carrier mothers and the

relationship of HBV amount between colostrum and maternal blood, 50

HBeAg-positive carrier mothers were recruited and studied for hepatitis

B surface antigen (HBsAg) titer, HBeAg titer, and HBV-DNA concentration

in their sera and colostra. According to the presence or absence of

seral HBV-DNA determined by dot hybridization, these 50 HBeAg-positive

carrier mothers could be divided into two groups: group 1 (n = 28,

HBV-DNA < 0.04 ng/ml), and group 2 (n = 22, HBV-DNA > or = 0.04

ng/ml). The colostral HBsAg and HBeAg titers were both significantly

higher in group 2 than in group 1. In addition, both colostral HBsAg

and HBeAg titers had positive correlation with each corresponding

maternal blood. Although the colostral HBV-DNA was undetectable by dot

hybridization, all were positive by polymerase chain reaction with

Southern blot hybridization. Because HBV-DNA can be detected in all

HBeAg-positive carrier mother's milk, it reinforces the necessity of

hepatitis B vaccination for the neonates born to these carrier mothers,

particularly in countries with a high carrier rate.PMID: 8229550 [PubMed - indexed for MEDLINE]

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