On 12/05/2007, at 23:16, laurie wheeler wrote:
> I didn't realize that morphine is a metabolite of codeine, and
> therefore the
> mother was not necessarily on morphine too. The news item says
> codeine and
> morphine were found in baby's blood from toxicology tests. It still
> does not
> all add up.
Is it alleged that the mother had the genetic variation ("ultrarapid
metaboliser") in the CYP2D6 enzyme? This can cause serious opioid
intoxication with just small doses of codeine. Here's another case
report:
https://content.nejm.org/cgi/content/abstract/351/27/2827
and this bulletin from the Canadian Pharmacists Association discusses
the issue:
http://www.pharmacists.ca/content/cpjpdfs/nov_dec06/
SafetyFirst_Madadi.pdf
Lara Hopkins
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