Reglan and Domperidone are both peripheral dopamine antagonists that boost 
prolactin levels. They are very closely related but Domperidone carries less risk 
of causing CNS problems, including depression, since it doesn't cross into the 
brain compartment,and is therefore the drug of choice for many practitioners. 
Since they will essentially do the same thing why would you want to give 
them both? It seems similar to giving aspirin and ibuprofen at the same time. 
But if you really want an answer to this question, why don't you e-mail 
Thomas Hale on his website? He will generally answer within 24 hours.

Kathy Lilleskov RN IBCLC

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