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Date: | Tue, 9 Jan 2007 10:25:55 -0500 |
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There is no mention of feeding methods in this study but am I wrong to
assume that these babies were fed with AIM?
Ellen Penchuk, IBCLC, RLC
Probiotic supplementation for the first 6 months of life fails to reduce the risk
of atopic dermatitis and increases the risk of allergen sensitization in high-risk
children: A randomized controlled trial
Angie L. Taylor, BSc Hons, Janet A. Dunstan, BAplSc, PhD, Susan L. Prescott,
MBBS, PhD, FRACP
Received 31 May 2006; received in revised form 25 August 2006; accepted 29
August 2006 published online 18 October 2006.
Perth, Australia
Background
Despite preliminary evidence, the role of probiotics in allergy prevention is
unclear.
Objective
To determine whether early probiotic supplementation prevents allergic
disease in high-risk infants.
Methods
Newborns of women with allergy (n = 231) received either Lactobacillus
acidophilus (LAVRI-A1) or placebo daily for the first 6 months of life. Children
were assessed for atopic dermatitis (AD) and other symptoms at 6 and 12
months and had allergen skin prick tests (SPT) at 12 months of age.
Results
A total of 178 infants completed the supplementation period. Those in the
probiotic group showed significantly higher rates of Lactobacillus colonization
(P = .039). At 6 months, AD rates were similar in the probiotic (n = 23/89;
25.8%) and placebo (n = 20/88; 22.7%) groups (P = .629). There was also no
difference at 12 months, although the proportion of children with SPT+AD was
significantly higher in the probiotic group (P = .045). At 12 months, the rate of
sensitization was significantly higher in the probiotic group (P = .030). The
presence of culturable Lactobacilli or Bifidobacterium in stools in the first
month of life was not associated with the risk of subsequent sensitization or
disease; however, the presence of Lactobacillus at 6 months of age was
associated with increased risk of subsequent cow's milk sensitization (P
= .012).
Conclusion
Early probiotic supplementation with L acidophilus did not reduce the risk of AD
in high-risk infants and was associated with increased allergen sensitization in
infants receiving supplements. The long-term significance of the increased
rate of sensitization needs to be investigated in further studies.
Clinical implications
These findings challenge the role of probiotics in allergy prevention.
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