In response to Narelle Clark's request for info on this medication=
and
breastfeeding, here is what I found in Briggs, Freeman and Yaffe,=
Drugs in
Pregnancy and Lactation (4th edition, 1994; p.570) "Methotrexate=
is
excreted into breast milk in low concentrations. Afater a dose of=
22.5
mg/day, mil concontrations oof 6x10-9 M (0.26=B5g/dl) have been measured=
with
a milk:plasma ration of 0.08. The significance of this small amount=
is not
known. However, because the drug may accumulate in neonatal tissues,
breastmfeeding is not recommended. the AAP consider methotrexate=
to be
contraindicated during breast feeding because of several potential
problems, including immune suppression, neutropenia, adverse effects=
on
growth, and carcinogenesis."
My question, as a NON-pharmacologist, is how great would those POTENTIAL
adverese effects be for a single dose? Anne Norton, if you are listening,
please reply. The small concentration suggests to me that those=
risks
would be very small. But, I am not the right person to be making=
such a
decision.
=20
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
%% "We are all faced with a series of great opportunities %%
%% brilliantly disguised as impossible situations." %%=
=20
%% definition of a lactation consulting service. %%=
=20
%% Kathleen G. Auerbach,PhD, IBCLC - [log in to unmask] %%
%% Homewood, Illinois USA %%=
=20
=20
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
=20
|