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Mon, 22 Aug 2005 12:51:50 EDT |
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In a message dated 8/22/2005 9:38:18 AM Pacific Standard Time,
[log in to unmask] writes:
My question still
stands as to why this was done and how can a conclusion be drawn that
outcomes from the use of donor milk are not different than those from
preterm
formula? It almost looks like the formula diluted any effect that donor milk
would
have on the 2 outcomes measured, late onset sepsis and occurrence of NEC.
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
The infants were switched because they were not growing adequately on the
PDBM plus fortifier. We don't allow inadequate nutrition for the sake of any
study.
I agree that receiving formula may have diluted the effect of the PDBM, but
remember, the study was not even started until all the infants reached 50 ml/kg
total milk intake (presumably their own mother's milk), to remove possible
bias from early morbidities of prematurity. Early nutrition (ie. what an infant
was started on) would be even more likely to affect the outcomes.
Intention to treat analysis is still the best way to treat this data per my
statistics experts.
Nancy
Nancy E. Wight MD, IBCLC, FABM, FAAP
Neonatologist, Sharp Mary Birch Hospital for Women and Children's Hospital
Medical Director, Sharp HealthCare Lactation Services
San Diego, CA
[log in to unmask]
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