Anna, I'll have a go, but I might also have the wrong assumptions.

The 150 mg shot is *one shot for the whole body's volume of blood* I guess,
and if I recall correctly, that is about 5 litres worth, 5000 mls.  If I
have mis-remembered, the calculations have to be altered at that point where
I have used 5000 mls.

150 mg per 5000 mls cancels down to 3 mg per 100 mls  (ie dividing both
figures by 50)
which is 3000 micrograms per 100 mls, or 30 micrograms per ml

So the shot is worth 30 000 ng/ml

My own question is: this shot has to last 3 months, so must be in a
slow-release form.  How much of the 30 000 ng is actually available to cause
an effect at any one time?  If the slow-release mechanism is really working,
then you should still divide by 90 days to get a figure per day, and then
perhaps by 24 hours to get a figure per hour etc etc, working somehow with
the half-life of DP, whatever that is......

This is very complicated - I'm not sure you can do it by arithmetic.  Going
eeny, meeny, miny, mo among the studies would probably be as valid a way of
estimating as any....and it's probably best to be conservative and delay as
long as possible the introduction of foreign goodies into anyone's body,
IMO.

Best wishes
Jacquie Nutt
South Africa

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