Hello everyone,
I seem to rember with the last days that people were talking about early
return of menses. Well, on my travels today I came across this article that
might be of interest. It is free online and I have included a link to the
homepage of the journal (the link to the actual artikel is about 2km long!).
http://humrep.oupjournals.org/
The abstract is under this message.
groetjes
Sara Bernard, The Netherlands
Hum Reprod. 2001 Dec;16(12):2540-5.
Plasma prolactin/oestradiol ratio at 38 weeks gestation predicts the
duration of lactational amenorrhoea.
Campino C, Torres C, Rioseco A, Poblete A, Pugin E, Valdes V, Catalan S,
Belmar C, Seron-Ferre M.
Department of Endocrinologia, Facultad de Ciencias Biologicas, Pontificia
Universidad Catolica de Chile, Santiago, Chile.
BACKGROUND: Fully breastfeeding women experience an amenorrhoea of variable
duration. Our aim was to identify in pregnancy, endocrine markers that could
predict the duration of subsequent lactational amenorrhoea. METHODS: We
studied 17 healthy women at 34 and 38 weeks gestation, and 1 and 3 months
post-partum. The women fully breastfed until 6 months post-partum. During
pregnancy, prolactin (PRL), oestrogens (total oestradiol, unconjugated
oestrone, unconjugated oestriol), sex hormone binding globulin (SHBG),
dehydroepiandrosterone sulphate (DHEA-S), progesterone and placental
lactogen, and during post-partum PRL, oestrogens and SHBG, were measured.
Free oestradiol in pregnancy and post-partum was calculated. RESULTS: Ten
women experienced long (>6 months) and seven experienced short (<6 months)
lactational amenorrhoea. At 38 weeks gestation, the women who experienced a
long lactational amenorrhoea had twice as much PRL, about half the total
oestradiol, lower SHBG concentration (P < 0.05, Student's t-test, Bonferroni
modification) and similar free oestradiol concentration, compared with those
who experienced short lactational amenorrhoea. The difference in PRL
concentration persisted in post-partum postsuckling samples. CONCLUSION: At
38 weeks gestation, the ratio PRL/oestradiol identified all individual women
according to the subsequent duration of their lactational amenorrhoea,
suggesting that duration of lactational amenorrhoea is conditioned during
pregnancy.
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