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Date: | Sun, 15 Feb 2004 15:23:57 -0000 |
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Bohlke K, Galil K, Jackson LA, et al.
Postpartum varicella vaccination: is the vaccine virus excreted in breast
milk?
Obstet Gynecol 2003;102(5 Pt 1):970-7.
OBJECTIVE: To evaluate whether the varicella vaccine virus is detected in
breast milk after vaccination of breast-feeding women and whether there is
serologic evidence of exposure of the infant to varicella virus after
maternal vaccination. METHODS: We enrolled women identified as varicella
seronegative during routine prenatal screening at Group Health Cooperative.
Participants received the first dose of varicella vaccine at least 6 weeks
postpartum and the second dose at least 4 weeks later. They collected ten
breast milk samples after each vaccine dose. Breast milk samples were tested
for varicella zoster virus by polymerase chain reaction (PCR). Serum
specimens were collected from the mothers 1 month after each vaccine dose,
and peripheral blood from their infants was collected onto filter spots 1
month after the mother's second dose. These samples were tested for
varicella immunoglobulin (Ig) G by whole-virus enzyme-linked immunosorbent
assay (ELISA), or by the more sensitive glycoprotein ELISA. When possible,
filter spots from the infants were also tested by PCR for the presence of
varicella zoster virus deoxyribonucleic acid (DNA). RESULTS: Twelve women
were enrolled; all seroconverted after the first vaccine dose. Varicella DNA
was not detected by PCR in any of the 217 postvaccination breast milk
specimens. None of the infants was seropositive. Samples from six infants
were tested for varicella zoster virus DNA by PCR, and all were negative.
CONCLUSION: We found no evidence of varicella vaccine virus excretion in
breast milk. These findings suggest that postpartum vaccination of
varicella-susceptible women need not be delayed because of breast-feeding
Available from: PM:14672472
Also
Smallpox Vaccination Information for Women Who Are Pregnant or Breastfeeding
http://www.bt.cdc.gov/agent/smallpox/vaccination/preg-factsheet.asp
Sheila Company (UK)
IBCLC, Health Visitor & NCT breastfeeding counsellor
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