Norma,
EMLA cream is a topical anesthetic (lidocaine & prilocaine) combination.
It must be in place for a hour to take effect, peaks within 2-3 hours &
last 1-2 hours after cream is removed.  Often less time with a neonate.  In
the hospital we apply to the skin & use a tegaderm to keep in contact with
skin & so won't rub off.  Once removed the skin will appear to look
blanched.

Hope this information helps you out!
Denise

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