A followup on Celiac disease and infants who are susceptible. CD is
terribly underdiagnosed in the US. It appears at least 1 in every 153
persons have it. In Italy where Dr. Fasano comes from it is 1 in 50
due to centuries of wheat pasta and bread consumption. Every child
in Italy is tested by the 3rd grade. When a child complains of
malaise, this is one of the first things tested for.
Judy Ritchie
========================================================================
Date: Wed, 8 Mar 1995 11:00:40 GMT
From: William Elkus ([log in to unmask])
Subject: Gluten in Breast Milk?
In the post from the Sprue-nik Press, it said:
)Dr. Alessio Fasano, University of Maryland
------------------------------------------
)A question was raised: Can a baby receive gluten through breast milk?
)Dr. Fasano stated that it has never been described that gluten can go
)through breast glands
Although I have never read the journal articles myself, Dr. Kalle
Reichelt, a Norweigan researcher,has cited several articles as evidence
that dietary proteins in general, and gluten/gliadin specifically, can
be
transfered to a breast-fed baby:
The following is from a post written by Reichelt to another internet
discussion group, but if you do a CELIAC archives search on 'reichelt'
you will find very similar posts on our own discussion group:
) ..food proteins can be demonstrated in mothers milk (3-6) as intact
) proteins. This could easily therefore take place also during
pregnancy.
) 3: Kilshaw PJ and Cant AJ (1984) The passage of maternal dietary
) protein into human breast milk. Int Arch Allergy and Appl
) Immunol 75: 8-15.
) 4: Axelsson I, Jacobsson I, Lindberg T, and Benediktsson B (1986)
) Bovine lactoglobulin in human milk .Acta Paed Scand 75: 702-707.
) 5: Stuart CA, Twiselton R, Nicholas M and Hide DW (1984) Passage
) of cow s milk protein in breast milk .Clin Allergy 14:533-535.
) 6:Troncone R, Scarcella A, Donatiello A, Cannataro P, Tarabusco A and
) Auricchio S (1987) passage of gliadin into human breast milk .
) Acta paed Scand 76: 453-456.
Since Ihave not read the articles, I have no idea whether the amounts of
these proteins would be sufficient to trigger a Celiac (or other
autoimmune) response in a susceptible child.
If anyone makes a copy of these articles and is willing to fax or mail
me a copy, please email me privately, as we are expecting another baby
soon.
Bill Elkus
[log in to unmask]
Date: Thu, 9 Mar 1995 13:41:28 GMT
From: William Elkus ([log in to unmask])
Subject: Fwd: Trace amount of protein in milk.
)From Dr. Reichelt in reply to my post yesterday, in which I wondered
)whether the amounts of gluten in mother's milk is significant:
Hi.
It should be stressed that the amount are small. However, the point is
that even trace amounts can be important because if the proteins are not
properly broken down peptides will accumulate. After all the uptake of
proteins from the gut into blood has also been demonstrated:Husby et al
(1985) passage of undegraded dietary antigen into the blood of healthy
adults .Scand j Immunol 22: 83-92.
Other references in brief :
Bloch KJ et al (1979) gastroenterology 77:1039-1044.
Thomas et al (1974)Immunology 27:631-639.
Walker WA et al (1974) gastroenterol 67: 531-550.
Because gluten contains at least 15 opioid sequences per molecule
(Fukudodme S-I and Yoshikawa M (1991) Opioid peptides derived from wheat
gluten :Their isolation and characterization .FEBS Letters 296:107-111.)
It is therefore clear that one molecule could theoretically give 15
opioids . This means that trace amount of peptide could quickly become
very important.
Cheers Tiny
K. Reichelt
Pediatric Research Institute
N-0027 Oslo, Norway
Tel: +47 22 86 90 45
Fax: +47 22 86 91 17
E-mail: [log in to unmask]
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