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Subject:
From:
Sarah Barnett <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Sun, 22 Oct 1995 15:56:17 EDT
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Hi
I did get and read:
Serum Nortriptyline Levels in Nursing Mothers and Their Infants
  Katherine L. Wisner M.D. M.S. and James M. Perel PhD
Am J Psychiatry 148:9, Sept. 1991 pp 1234 -36

Abstract: "The nortriptyline levels of 7 depressed mothers and
their breast-fed infants were obtained.  Nortriptyline was not
detected in the infants' sera.  However, two of four infants
evaluated developed low concentrations of 10-hydroxynortriptyline.
No adverse effects were observed."
The authors do also acknowledge the fact that the decision
about continuing to breastfeed during antidepressant therapy
is complex and involves values and that the "available
information does not warrant absolute recommendations."

Additional references in the bibliography that might prove
helpful are:
Amitriptyline in human breast milk and the nursing infant's serum
  TF Bader & K. Newman
Am J Psychiatry 1980; 137:855-856

Amitriptyline and nortriptyline excretion in human breast milk.
  L. Brixen-Rasmussen, J. Halgrener, A. Jorgensen
Psychopharmacology 1982; 76:94-5.

Tricyclics and breast feeding (letter)
  SH Erickson, GH Smith, F. Heidrich
Am J Psychiatry 1979; 136:1483

Hope this is helpful.

Sarah Friend Barnett, M.A., LLL leader, IBCLC
Bronx (New York City), NY
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