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Subject:
From:
Tom Hale <[log in to unmask]>
Reply To:
Lactation Information and Discussion <[log in to unmask]>
Date:
Tue, 2 Sep 1997 12:22:29 -0500
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Interesting...  I loaded my '97 database to 'fix' the parlodel sentence,  and
found that it did state "maternal side effects" as below...

"Anti-parkinsonian, synthetic ergot alkaloid which inhibits prolactin secretion
and hence physiologic lactation.  Most of the dose is absorbed first-pass by
the liver, leaving less than 6% to remain in the plasma.  Maternal serum
prolactin levels remain suppressed for up to 14  hours after a single dose.
The FDA approved indication for lactation suppression has been withdrawn,  and
it is no longer approved for this purpose due to numerous maternal deaths,
seizures,  and strokes.  Observe for transient hypotension or vomiting.  It is
sometimes used in hyperprolactinemic patients who have continued to breastfeed,
although the incidence of maternal side-effects is significant.  Bromocriptine
should only be used in lactating women for short periods if at all.   In one
breastfeeding patient who received 5 mg/day for a pituitary tumor,   continued
lactation produced no untoward effects in her infant.  Profound postpartum
hypotension has been reported. "


I've noted this many times before, and it's understandable with all editions
I've published,  that people will often quote something from an earlier
edition, which may have changed significantly in a newer one. In this case, my
96 edition did not have the "maternal" added.  I evidently fixed it this year
when proofreading.

So I would really appreciate it if when quoting me, you would put the year or
edition from which you are quoting.  It may help to make some issues clearer to
all of us.

Thanks

Tom Hale

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