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Subject:
From:
C Hooper <[log in to unmask]>
Reply To:
Informed Discussion of Beekeeping Issues and Bee Biology <[log in to unmask]>
Date:
Sun, 27 Jan 2008 05:33:12 -0700
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Study Investigates Anti-Arthritic Effect of Bee Venom

Effects of Melittin on the Production of Matrix Metalloproteinase-1 and
-3 in Rheumatoid Arthritic Fibroblast-Like Synoviocytes
Journal of Pharmacological Sciences, Vol. 106 (2008) , No. 1 pp.162-166 
http://apitherapy.blogspot.com/2008/01/study-investigates-anti-arthritic.html

Bee venom (BV) has been used in patients with arthritis, including
rheumatoid arthritis, to reduce pain
and edema . In the arthritic rat model, BV has been shown to act as an
anti-inflammatory adjuvant and to reduce LPS-induced inflammatory edema
and polyarthritis . The hydrophilic peptide melittin, the
major active ingredient of BV, may retain anti-RA activity in rabbit
models of immune-mediated arthritis. 

We have previously shown that melittin downregulates MMP-3 expression in
human osteoarthritic
chondrocytes . Here, we examined the effects of melittin on MMP1 and
MMP3 production in human FLS obtained from RA patients...

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