This is the article I referred to in my last posting on disulfiram: In the suckling rat, the low affinity hepatic aldehyde dehydrogenase component in the newborn was different than that in the adult as assessed by kinetic studies and by its sensitivity to disulfiram. Nevertheless, the fact that acetaldehyde was not detected after ethanol ingestion in suckling rats, suggests that there is enough hepatic aldehyde dehydrogenase activity to metabolize all the acetaldehyde generated in liver by alcohol dehydrogenase. Suckling rats = suckling human beings in this case-who knows? But this information does add somewhat to our overall knowledge. Frank J. Nice, DPA, CPHP