Aaron Morris wrote: Well said Aaron. I would like to add (for the laic) that abuse and lack of attention to the prescribed and much recommended instructions, development of resistance is one of the problems that we face in the practice of medicine, be it human or veterinary. There is nothing that the practitioner of manufacturer can do to remedy the harm once it is done. I have long feared that that is precisely the problem with Apistan strips. Those of you who have read my file will remember that I mentioned that I bought a number of hives (severely infested by Varroa mites) and that treatment with Apistan strips did absolutely nothing to the mites. (Did the previous owner exceed recommended dosage?) Altering the physical characteristics of the strips could be releasing more than intended amounts of the pesticide (thus increased efficacy noted). HOWEVER, that increased amount of the active ingredient is going to be incorporated to the brood chamber and its contents. BEWARE of the consequences! I think that the writing is on the wall! Best regards. Dr. Rodriguez Virginia Beach, VA