Jay, I don't know if your questions about this herbal antidepressant have been answered, but I want to share a website with you. http://www.hypericum.com/toc.htm It's very informative and clearly written. From the responses I've seen, it doesn't look like anyone can say "for sure" if there is any effect on milk supply or reactions in infant. If that is the case, how does the mother feel about giving this a "trial"? If she takes the herb in moderation and watches for a change in milk supply, or change in baby's temperament, she can give us some very useful feedback. What is the alternative? Continue in a state of depression without treatment; take a known medication while breastfeeding; stop breastfeeding with the known associated risks. Please let us know what she decides. Jeanne Fisher Austin, TX