Edie-- I don't have a lot of experience, but I can tell you what Dr. Randall Craig, an infertility specialist in Arizona who works with induced lactation cases, has to say. I spoke with him a couple of years ago, and asked him about the depression issue. He told me that 25% of women may develop depression if they used metoclopramide [reglan] for over 3 mos. He seems to have extensive experience following moms, and has some who will breastfeed and take the drug for a whole year. I'll be interested to see what other people's experiences have been. -Lisa Marasco BA, IBCLC