There is a brand new product available from Upjohn which releases estrogen locally only (company literature insists no systemic absorption) from a Silastic ring . The ring contains a three month supply of the estradiol. Of course, the drug rep I saw in my office last week immediately added that the product is not approved for use in lactation! However, if there is no systemic absorption, it ought to be ideal for this indication. I am very eager to offer this to my patients--just haven't had a lot of time to do so since it's a new product here in the USA. (Lots of European experience with post-menopausal vaginal absorption studies, per the manufacturer.) Any one out there in LactLand who has had a chance to use this in Europe or elsewhere? Up until now, BTW, I've prescribed small doses of estradiol cream with good results. Systemic absorption from the cream is negligeable after the vaginal epithelium thickns up, which takes about 2 or 3 weeks. Lisa G. Matthews, M.D. FACOG, Stamford, CT.