Hi Lactnetters (Dr. Hale?) I have a question about the safety of the Topical Cream 5% Efudex. According to 'Drugs in Pregancy and Lactation - A Regerence Guide to Fetal and Neonatal Risk' by Briggs, Freeman and Yaffe, Efudex (not the topical cream) is known as Fluorouracil. Fluorouracil is listed in this book and in Dr. Hale's book as a potent antineoplastic agent used for therapy in various carcinomas. No data is available on its transfer into breastmilk. Dr. Hale says it's not recommended for breastfeeding mothers. Briggs says no data are available for breastfeeding. This mother was prescribed this cream to apply to a wart on the sole of her foot. She is breastfeeding a toddler. She has discontinued its use but was told the drug would stay in her system for up to a month. Would this also be true for the topical cream? Naturally she wants to continue breastfeeding, and is now worried.... TIA for any replies. Janaki Costello, IBCLC El Cerrito, CA. [log in to unmask]