Ann C. Fludeoxyglucose is an analog of glucose that enters most all tissues of the body according to their metabolic rate. The radioactive ion 18(F), has a half-life of 110 minutes. It would undoubtedly enter breast milk. I would recommend to pump and discard milk after the procedure to reduce radioactive exposure of the breast tissue. The manufacturer recommends routine bladder emptying for the same reason. According to the USPDI(1982) the mother should wait 12-24 hours before breastfeeding her infant. In 9 hours, 97% of the isotope will be decayed away. Were the mother to pump and dump for 12 hours, and then feed her infant, certainly most all of the radioactive fluoride would be gone. Tom Hale FLUDEOXYGLUCOSE F 18 ((18)F) is E.Clin Appl rapidly cleared from plasma after intravenous doses, and F.Reference enters cells in a manner similar to glucose; it is G.Author phosphorylated intracellularly by hexokinase to fludeoxyglucose F 18-6-phosphate but, unlike glucose-6-phosphate, is not metabolized further. Uptake and accumulation of (18)F in tissues occurs in proportion to the rate of glucose metabolism, and this can be measured by PET; hypometabolism or hypermetabolism of CUUP Up 1 Line glucose is characteristic of many diseases. Uptake of PREV Up 1 Page (18)F is greatest in the bladder wall, heart, spleen, and NEXT Dn 1 Page brain. Up to 20% of an intravenous dose of (18)F is F11 Last Menu excreted in the urine within two hours. The physical F1 HELP half-life of (18)F is 110 minutes.