Hi All, From Hale, Pg 259 AAP: Not reviewed Metformin is used to reduce glucose levels in non-insulin dependent diabetics. Ora; bioavailability is only 50%. Whereas plasma half-life is 6.2 hours, whole blood half-life is 17.6 hours. Studies in animals suggest a milk:plasma ratio of 1.0 with milk levels comparable to the maternal plasma. No data from human studies were found. Due to low protien binding, and the low molecular weight (165) of this product, other hypoglycemics would be preferred. Adverse Effects: Diarrhea, nausea, vomiting, bloating, lactic acidosis, hypoglycemia AHL = 6.2 hours (Plasma) M/P = 1.0 PHL = PB = Minimal PK = 2.75 hours Oral = 50% Hope this helps! Jay Simpson, CLE Who loves her Hale!