Jo Mihalik (hi Jo!) asked about Flagyl. From Dr. Hale's "Medications and Mother's Milk" - Antibiotic, amebicide. Do not give during fist trimester of pregnancy, can be mutagenic and carcinogenic. Following a 2 gm oral dose, milk levels were reported to peak at 50-57 mg/L at 2 to 4 hours...milk levels after 24 hours were approximately 10 mg/L. Following a dose of 250 mg three times daily, the average milk level was 6 mg/L. For treating trichomoniasis, recommend 2 gm single oral dose, and discontinue breastfeeding for 24 hours, then reinstitute. AHL = 8.5 hrs. PB = 10%. PHL = 25-75 hrs (full term infants). AAP Reason for Concern. Hope this helps. Cathy Kaiser, LLLL Franklin, TN [log in to unmask]