Katie: There have been some good entries about antidepressants in the past. I'll refer you to the archives, with a particularly relevant posting from Dr. Hale on Oct. 24, as well as Dr. Hale's post on Nov.27, Jon Ahrendsen on Sept 27 and Sarah Barnett on Oct. 22. Bottom line is that the tricyclic antidepressants (e.g. desipramine, amitryptilene) tend to have very minimal blood levels in babies and that there are no known long-term adverse effects (by the same token, the long-term effects are really unknown, so even these agents must be used with caution, as per the AAPrecommendation). As for the SSRI's (prozac, sertraline, paroxetine), there is less known about these, and prozac is of particular concern because of its long half-life, but even though sertraline has been shown not to have any significant drug levels in babies, the levels of metabolites were not measured, so it's still an unknown). Read the archives for more details, but probably tricyclics such as desipramine and amitryptilene are the better choices. Alicia. [log in to unmask]