Hi all There have been some reports of nipple irritation if mothers put lactaid directly onto their nipples. Also, as lactaid is an enzyme, it would be rapidly broken down by acid in baby's stomach, and would thus have no effect. It will only work if left in milk for 24 hours or so, (eg adding it to ebm). This is a lot of messing around, and should be a last resort for babys who are truely lactose intolerant, rather than 'colicky'. IMHO ! Fiona Coombes MBBS IBCLC Perth Western Australia