RE Denise Parker's case: >> Mother has a history of very low levels of estrogen. They used "mega doses" (her term) of clomid to enable her to conceive.<< Lawrence (1994 ed) in her section on physiology has many references to estrogen's involvement in breast development. I found this one that seems to indicate that lack of estrogen is not the problem: " Estogens enhance the effect of prolactin on mammogenesis but antagonize prolactin by inhibiting the secretion of milk." (pg 66) >>Her breasts were very assymetrical as a teen and she had reduction in one to even them out. They are still assymetrical but neither is producing. I immediately thought of insufficient mammary tissue however they look normal with no tubular shape to them at all.<< From your comments, it sounds more like lack of tissue. I have found that shape is irrevelent with insufficent glandular development. How about an ultra sound of the breasts? Re: Linda's Smith's case When a woman is morbidly obese (you din't say how overweight this mom is) my understanding is that they have problems with high estrogen levels. A friend is more than 100# overweight and has very irregular periods. The GYN says excessive body weight is related to overproduction of estrogen causing a rebound effect making the periods irregular. She was told it is not unlike the effect of BCP's. She has also been warned that she would be more likely to get breast cancer. I know of many women who were seemly infertile until they lost weight. Given this mom's weight and overproduction any chance she has a pitutary tumor or other hormonal imbalance?