A woman called with sudden onset of mastitis. She has been taking low doses of aspirin prophylactically, she wasn't sure why but felt it was probably to prevent a recurrence of blood clots in the legs. Does anyone feel that the aspirin (or alternatively, a clot) could be part of the picture with sudden onset of mastitis (no plugged ducts before, but a definite plug the day of the mastitis--couldn't uncover any other "typical" cause for her mastitis--damage, fatigue, poor diet, etc., although of course *something* precipitated it. In just a matter of hours she went from feeling well, with no plugs or any other nipple or breast problems, to having full-blown mastitis, with fever, feeling terrible, hard red area on her breast, etc. Just wonder if the aspirin ingestion over 2 months' time could possibly have any role. I don't know the physiological mechanism of its anticoagulant activity and so can't extrapolate to possible changes in other cellular structures. Arly Helm [log in to unmask] (Arly Helm, LC)