In response of use of ibuprofen, I need to add the info that ibuprofen is indeed hepatoxic. I have found antiinflammatories as a group a common culprit in etiology of abnormal liver enzyme tests, and MDs know to screen liver function tests on all people who regularly use anti-inflammatories. My most memorable case is a woman who was taking ibuprofen only for 1 day every month for pain with her menses. On screening labs one year, her liver tests were elevated, and after a thorough evaluation, once she stopped the infrequent use of ibuprofen, the problem immediately resolved! And, theoretically, Reyes syndrome can be caused by any analgesic. All analgesics can also cause renal damage. So...pick your toxin....nothing is 100% safe. Anne Eglash, MD